This article examines the "Other Canon" economic schools, which present alternative views to the dominant neoclassical theory, and their approaches to regional economic development in Uzbekistan. It analyzes how institutionalism, structuralism, and Marxism explain regional inequalities, center–periphery dynamics, and the significance of state intervention. Based on the theoretical foundations of these heterodox schools, the author proposes practical recommendations for revising regional development policies in the context of Uzbekistan.