This study evaluates the nonlinear relationship between living standards and economic growth in the Qashqadaryo region during 2010–2024 using the ANFIS (Adaptive Neuro-Fuzzy Inference System) model. Based on semi-synthetic data close to real statistics, key indicators include income index, infrastructure, and digital infrastructure. The ANFIS model demonstrated high accuracy (R² = 0.977), revealing a strong synergy between income and digitalization, with 3D surface analysis highlighting digital infrastructure as a key growth driver. The results provide practical guidance for regional development strategies