The article analyzes the role of international financial institutions in financing innovative projects and their implementation. The strategy, financial instruments, and technical assistance of such large financial institutions as the World Bank, the Asian Development Bank, and the International Monetary Fund in supporting innovations will be highlighted. At the same time, the effectiveness of cooperation with international institutions based on the experience of the CIS countries, in particular Uzbekistan, will also be considered. The article provides an in-depth analysis based on the views of scientists, practical examples, existing problems, and promising proposals.